Fresh analysis reveals that people who discontinue new slimming jabs like Mounjaro or Wegovy may regain reduced body mass far faster than those who halt traditional diet and exercise plans.
Published data in a major health publication shows that while obese people frequently drop about a fifth of their body weight while on the medication, the mass returns at an estimated rate of nearly a kilo each month after stopping.
"Users using such medications must be aware of the danger of fast rebound weight gain when the treatment concludes," stated researcher Dr. Susan Jebb.
Such speed of recovery suggests a return to starting weight within about a year and a half.
Weighing Treatments
The research, which looked at dozens of trials involving thousands of patients, contrasted the outcomes of these new drugs with conventional dieting.
Scientists note that individuals who shed pounds through lifestyle changes alone typically see a less rapid weight regain—perhaps 100 grams monthly—once they finish.
Explaining the Fast Regain
Experts suggest the mode of action of the drugs is key to understanding the heightened regain.
The injections mimic a body's own chemical called glucagon-like peptide-1, which moderates appetite.
"Sustained high doses of the hormone concentrations far above than normal might result in the system to produce less of its endogenous hormone, and may also diminish sensitivity to its actions," noted Dr. Adam Collins, a nutrition researcher.
"Stopping of this hormone supplement leads to hunger is unsuppressed, making overeating much more probable."
A Lifelong Disease?
Health authorities recommend the jabs for individuals with weight-linked medical conditions, alongside prescribed diet and exercise modifications.
Professionals contend that, due to the high risk of weight regain, the therapy is often ongoing.
This opinion is reinforced by drug manufacturers, who say that the findings "underscore the persistent character of obesity," akin to managing conditions like hypertension.
User Testimonies
People who have discontinued the jabs describe a powerful return of hunger.
"It was like a switch activating and I was suddenly ravenous," recalled an individual.
This challenge is exacerbated if patients have not adopted lasting lifestyle or habit changes during therapy.
Significant Use
Survey data indicate that a significant number of adults in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Use is greater among women than males.
- The 40s and 50s age group shows the greatest usage rates.
- Many access the drugs through private healthcare rather than public health services.
Finally, researchers emphasize that while the jabs are potent agents for shedding pounds, they are not a standalone fix and lasting health benefits hinges on ongoing behavioural support.